The future of canine stem cell therapy: unprecedented, painless, and feeder-free

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Scientists create canine iPSCs from urine-derived cells with high efficiency

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Credit: Shingo Hatoya, Osaka Metropolitan University

Osaka, Japan – Dog owners may have to learn to appreciate their best friend’s urine. Scientists at Osaka Metropolitan University have developed an efficient, non-invasive, and painless method to reprogram canine stem cells from urine samples, taking furry companions one step further. which is closer to veterinary regenerative treatment.

Induced pluripotent stem cells (iPSCs) are widely used in studies of human generative medicine. With the growing importance of advanced medical care for dogs and cats, there is an expectation that new therapies using iPSCs will be developed for these companion animals, as previously for people. Unfortunately, canine somatic cells show low reprogramming efficiency compared to humans, which limits the types of canine cells that can be used for generating iPSCs. IPSC induction often involves the use of feeder cells from different species. However, considering the associated risks, the minimization of xenogeneic substances is always advised, which means that it is necessary to improve the effectiveness of reprogramming different types of canine cells in dogs without using the feeder cells.

A research group led by Professor Shingo Hatoya and Dr. Masaya Tsukamoto from the Graduate School of Veterinary Science at Osaka Metropolitan University has identified six reprogramming genes that can increase canine iPSC generation by about 120 times compared to conventional methods using fibroblasts. iPSCs are created from cells obtained from urine using a non-invasive, straightforward, and painless method. In addition, the researchers succeeded in generating canine iPSCs without feeder cells, a feat that was impossible until now. The team aims to disseminate their findings to the global research community, contributing to the development of regenerative medicine and genetic disease research in veterinary medicine.

“As a veterinarian, I have examined and treated many animals,” explained Professor Hatoya. “However, there are still many diseases that cannot be cured or are not fully understood. In the future, I am committed to continue my research on the differentiation of canine iPSCs into different types of cells and apply them to the treatment of sick dogs, hopefully bringing happiness to many animals and their owners. .

Their findings are scheduled for publication in the Stem Cell Reports on December 21, 2023.

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About OMU

Osaka Metropolitan University is the third largest public university in Japan, formed through a merger between Osaka City University and Osaka Prefecture University in 2022. OMU supports the “Convergence of Knowledge” through 11 undergraduate schools, one college, and 15 graduate schools. For more research news, visit https://www.omu.ac.jp/en/ or follow us on Twitter: @OsakaMetUniv_enor Facebook.


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