The risk of heart disease is high with high cholesterol, hypertension before 55

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Experts say it is important to monitor blood pressure in young people. Fuse/Getty Images
  • Researchers report that hypertension and high cholesterol before the age of 55 may increase the risk of heart disease later in life.
  • They note that this risk remains, even if the individual takes steps to control these conditions after the age of 55.
  • Researchers say heart disease is often the result of a combination of risk factors, including genetics. However, as people age, genetics play a smaller role.

Having high blood pressure and/or high cholesterol before age 55 increases the risk of heart disease, even in people who develop those conditions as they age.

Those findings about a study published today in the journal PLOS ONE.

The researchers used a 3-sample randomization analysis of participants registered with the UK Biobank.

There are three analysis groups:

The researchers noted that if high LDL-C and SBP can be predicted based on genetics, there is a risk of coronary heart disease, regardless of age at diagnosis.

They also pointed out that those with high SBP and LDL-C in early to middle life had an increased risk of coronary heart disease, independent of their SBP and LDL-C levels in later life.

The researchers also noted that coronary heart disease is often the result of cumulative exposure to risk factors, such as SBD and LDL-C, and this may have long-term implications for a person’s risk.

They added that the effects of SBP on coronary heart disease decreased with age, none of which could be due to a previous observation that the genetic effects of some diseases begin to weaken later in life.

In their discussion of the study results, the researchers also pointed out that their findings are consistent with randomized controlled trials that suggest that the use of blood pressure medications and statins can help, even in aging. Despite this, they say that the use of statins and blood pressure drugs often decreases with age.

The researchers suggest that treating young people with elevated SBP and/or LDL-C is important to reduce their lifetime cumulative exposure.

Our findings suggest that aging alone is not a factor in preventing inappropriate LDL-C and BP-lowering treatments, as the effect of genetically mediated LDL-C and SBP on incident risk. [coronary heart disease] constant throughout life, they wrote.

We know that high blood pressure and high cholesterol are risk factors for heart disease, said Dr. Cheng-Han Chen, an interventional cardiologist and medical director of the Structural Heart Program at MemorialCare Saddleback Medical Center in California was not involved in the research. . This study examines the relationship over a long period of time and increases our understanding of the relationship in different age groups.

It won’t change how I treat my patients like I treat hypertension and high cholesterol throughout a person’s life, Chen said. Medical News Today. I have treated people under 55 for high cholesterol and high blood pressure.

Dr. Yu-Ming Ni, a cardiologist and lipidologist at the MemorialCare Heart and Vascular Institute at the Orange Coast Medical Center in California who was not involved in the study, agreed that the research would not change his general scope of treatment.

However, Ni said she could have been more aggressive in managing cholesterol at a younger age.

I can talk to my younger patients who have more opportunities to make dietary/lifestyle changes, better explain the risks, and work with them on the changes they can make in their everyday life, he said. Medical News Today.

As we get older, other factors take over, such as smoking, sedentary lifestyle, and bad eating habits, and replace the role of genetics, added Ni. If that happens, we need to change these things to reduce the risk of high cholesterol. This study shows that the longer you have high cholesterol, the higher your chance of heart disease.

I like studies using the UK Biobank because they have a large pool of people to draw from, Ni said. The results are reliable.

The researchers note that their study has limitations. For example, the use of antihypertensives and lipid-lowering drugs varies between age groups. To help account for this, the researchers adjusted SBP and LDL-C based on treatment status.

Experts say that lifestyle factors play an important role in high cholesterol and blood pressure.

According to Centers for Disease Control and Prevention (CDC), some of the risk factors for high blood pressure include:

  • Bad food, especially those high in sodium and low in potassium
  • Physical inactivity
  • obesity
  • Alcohol abuse
  • Smoking or other tobacco use

the CDC Lists risk factors for high cholesterol such as:

Poor diet, obesity, physical inactivity, and smoking are on both lists.

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